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| Description Linezolid is an oxazolidinone antibiotic that exhibits antibacterial activity against gram positive bacteria. Linezolid binds to the A site of 23S rRNA on the 50S ribosomal subunit, inhibiting protein synthesis. Linezolid also decreases NMDA receptor-mediated current, but is less active than most other comparable antibacterial compounds. |
| Specifications |
| Cas No. | 165800-03-3 | | Product ID | L3453 | | Product Name | Linezolid 分析标准品 | | Formula | 分子式 ：C16H20FN3O4 | | Formula Wt. | 分子量：337.35 | | Purity | 纯度 >98% | | Solubility | Moderately soluble in water (3 mg/mL). Soluble in DMSO (>20 mg/mL). | | References | Long KS, Vester B. Resistance to linezolid caused by modifications at its binding site on the ribosome. Antimicrob Agents Chemother. 2012 Feb;56(2):603-12. PMID: 22143525.
Kombian SB, Phillips OA. In vitro electrophysiological investigations of the acute effects of linezolid and novel oxazolidinones on central nervous system neurons. Neuroscience. 2011 Apr 28;180:53-63. PMID: 21296129.
Ippolito JA, Kanyo ZF, Wang D, et al. Crystal structure of the oxazolidinone antibiotic linezolid bound to the 50S ribosomal subunit. J Med Chem. 2008 Jun 26;51(12):3353-6. PMID: 18494460. | |
